Biscuit Pizza Casserole

There’s something wonderfully comforting about turning two family favorites into one easy dinner. This Biscuit Pizza Casserole brings together fluffy refrigerated biscuits, savory seasoned ground beef, pepperoni, rich marinara sauce, and plenty of bubbling mozzarella for a hearty meal the whole family can enjoy.

It has all the familiar flavors of a loaded pizza, but instead of dealing with a traditional pizza crust, everything comes together in one baking dish. With just 10 minutes of prep, it’s an especially handy recipe for a cozy weeknight dinner, casual family meal, or relaxed weekend gathering.

Why You’ll Make This Again

This casserole is the kind of easy comfort food that makes dinner feel a little more fun. The biscuit crust becomes golden around the edges while staying soft underneath the hearty layers of sauce, beef, pepperoni, and melted cheese.

• Easy weeknight dinner: The ingredients are simple, familiar, and require very little preparation.
• Pizza night made easier: You get all the classic pizza flavors without rolling or stretching pizza dough.
• Hearty and filling: Ground beef and mozzarella make this a substantial main dish.
• Family-friendly: Pepperoni, marinara, biscuits, and cheese are an easy combination for both kids and adults.
• One-dish convenience: Everything bakes together in a single casserole dish.
• Great for leftovers: Slices reheat easily for another quick meal.

How This Comes Together

The biscuit dough forms the base of the casserole, creating a soft, golden crust underneath the pizza toppings. Marinara goes over the dough, followed by browned ground beef, pepperoni, and a generous layer of shredded mozzarella.

The key is to spread the biscuit dough evenly across the bottom of the baking dish so the crust bakes at a consistent thickness. Once the toppings are layered over it, the oven does the rest, turning everything into a bubbling, cheesy casserole with golden edges.

What You’ll Need

You only need five main ingredients to make this easy pizza-inspired casserole. Browning the beef ahead of time keeps the assembly quick and gives the finished dish plenty of savory flavor.

• 2 cans refrigerated biscuits — These create the soft, fluffy casserole crust.
• 2 lbs ground beef, browned — Adds hearty, savory flavor throughout the casserole.
• 2 cups marinara sauce — Provides the rich tomato base and classic pizza flavor.
• 1 package pepperoni — Adds the familiar salty, savory flavor of a loaded pizza.
• 2 cups shredded mozzarella cheese — Melts over everything into a golden, bubbly topping.

Step-by-Step Directions

Step 1: Build the Biscuit Crust

Preheat your oven to 375°F and grease a large baking dish. Press the refrigerated biscuit dough evenly across the bottom of the dish, gently working it toward the edges to create the crust.

Try to keep the dough at a relatively even thickness so the center and edges bake at the same rate.

Step 2: Add the Marinara and Ground Beef

Spread the marinara sauce evenly over the biscuit dough, leaving the surface well covered. Sprinkle the browned ground beef evenly over the sauce so every portion gets a hearty layer of meat.

Step 3: Layer on the Pepperoni and Mozzarella

Arrange the pepperoni over the ground beef, spreading the slices across the casserole so you get pepperoni in every serving. Finish with the shredded mozzarella, covering the toppings generously.

Step 4: Bake Until Golden and Bubbly

Bake for 25–30 minutes, or until the biscuit crust is golden and the mozzarella is melted, bubbling, and lightly browned in spots. The finished casserole should look deeply golden around the edges with the cheese bubbling across the top.

Let the casserole rest for 5 minutes before slicing. This gives the layers a chance to settle and makes the pieces easier to serve.

How to Serve It

Cut the casserole into generous squares and serve while the cheese is still warm and stretchy. A simple green salad or crisp vegetables make an easy fresh side for such a hearty main dish.

For an extra pizza-night spread, serve it alongside our 2-Ingredient Cottage Cheese Flatbread and turn the meal into a casual assortment of bread, pizza flavors, and dipping sauces.

It’s also a natural choice for game-day gatherings, casual potlucks, or family movie nights when you want something filling that can be portioned straight from the baking dish.

Leftovers & Storage

Let leftover casserole cool, then cover it tightly and refrigerate. For the best quality, enjoy it within a few days. Store individual portions in airtight containers for easy reheating.

Reheat individual slices in the microwave until warmed through, or use a 325°F oven for a gentler reheating method that helps the biscuit crust retain more of its texture. If reheating several portions, cover the casserole loosely with foil so the cheese does not brown too quickly.

If you are preparing this for a gathering, the ground beef can be browned ahead of time and refrigerated until you are ready to assemble the casserole. This makes the actual preparation especially quick.

Make It Even Better (Pro Tips)

• Spread the biscuit dough evenly: An even crust helps the casserole bake consistently from edge to center.
• Brown the beef thoroughly: Cook and crumble the ground beef before assembling so it is ready to layer into the casserole.
• Drain excess grease: If the browned beef releases a lot of fat, drain it before adding it to the casserole.
• Cover the surface with cheese: A generous layer of mozzarella helps seal in the toppings and creates that classic bubbling pizza finish.
• Let it rest: Give the casserole 5 minutes after baking before cutting so the layers are easier to portion.
• Watch the edges: The biscuit crust should be golden and cooked through before removing the casserole from the oven.
• Slice with a sharp knife: A clean cut through the melted cheese and biscuit crust makes serving much easier.

Easy Ways to Change It Up

• Supreme Pizza: Add sliced mushrooms, diced bell peppers, or onions between the beef and cheese.
• Sausage and Pepperoni: Replace part of the ground beef with browned Italian sausage for a richer pizza flavor.
• Extra Cheesy: Add a little shredded Parmesan or provolone along with the mozzarella.
• Spicy Pizza: Use hot Italian sausage or add sliced jalapeños and red pepper flakes.
• Vegetarian: Skip the ground beef and load the casserole with mushrooms, bell peppers, onions, and olives.
• Hawaiian-Inspired: Add small pieces of cooked ham and pineapple for a sweet-and-savory variation.

Quick Questions

Can I use a different type of ground meat?

Yes. Ground Italian sausage, ground turkey, or a mixture of ground beef and sausage can all work. If using sausage, remember that it may already contain a good amount of seasoning and salt.

Can I add vegetables to Biscuit Pizza Casserole?

Absolutely. Diced bell peppers, mushrooms, onions, black olives, and other pizza-friendly vegetables are easy additions. For vegetables that release a lot of moisture, sauté them first so the casserole does not become watery.

Why should I let the casserole rest before slicing?

A short 5-minute rest allows the hot cheese and sauce to settle slightly and gives the biscuit crust time to firm up. This makes the casserole easier to cut into neat portions without immediately spilling the layers.

Can I use homemade pizza sauce instead of marinara?

Yes. Pizza sauce works very well here and will give the casserole a more traditional pizza flavor. Marinara is slightly more versatile and brings a rich tomato flavor that works beautifully with the biscuit crust.

What cheese works best besides mozzarella?

Provolone, Monterey Jack, or a combination of mozzarella and Parmesan can all be used. Mozzarella remains the best choice for the classic stretchy pizza-style topping, while a little Parmesan can add extra savory depth.

Prep Time: 10 minutes | Cook Time: 30 minutes | Total Time: 40 minutes | Serves: 8 | Calories: 610 per serving | Protein: 32 g per serving

“When pizza night needs to be easy, this is the kind of casserole I love most—golden biscuits underneath, savory beef and pepperoni in the middle, and a blanket of bubbling mozzarella on top.” — Ava